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Quadruple wild-type (WT) GIST: defining the subset of GIST that lacks abnormalities of KIT, PDGFRA, SDH, or RAS signaling pathways.

Cancer Med. 2014 Aug 28.


Pantaleo MA, Nannini M, Corless CL, Heinrich MC.


A subset of GISTs lack mutations in the KIT/PDGFRA or RAS pathways and yet retain an intact succinate dehydrogensase (SDH) complex. We propose that these KIT/PDGFRA/SDH/RAS-P WT GIST tumors be designated as quadruple wild-type (WT) GIST. Further molecular and clinicophatological characterization of quadruple WT GIST will help to determine their prognosis as well as assist in the optimization of medical management, including clinical test of novel therapies.

© 2014 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.


BRAF; GIST; NF-1; RAS; SDH deficiency; SDHA; SDHB; gastrointestinal stromal tumors; quadruple WT; quadruple negative; wild type

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